Alupent 20mg 30 Tabs, Metaproterenol, Orciprenalina
THIS IS THE BRAND MEDICATION
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Each vial contains:
Metaproterenol sulfate ..... 500 mcg
Vehicle c.b.p. 1 ml.
Each tablet contains:
........ Metaproterenol sulfate 20 mg
Excipient, c.b.p. 1 tablet.
Bronchodilator. Indicated for the treatment of bronchial asthma and of reversible bronchospasm in chronic bronchitis and emphysema, and bronchial spasm induced by the use of beta-blockers agents.
Inhibiting uterine contractility. Tocolytic to inhibit premature uterine contractions after the 20th week. and until the 37th week. pregnancy, or to achieve lung maturity of the product.
It is also indicated when uterine relaxation is required as in the cases of fetal distress, while obstetric problem is solved.
After administration of a dose of metaproterenol sulfate orally, it is absorbed through the gastrointestinal tract and peak plasma concentrations between 0.75-3.0 times are recorded, has a half life of 2.1 hours, it is metabolized in the liver as a result of first step. About 45% of the administered dose reaches the circulation and excreted unchanged in the urine, conjugated with glucuronic acid.
It administered intramuscularly or intravenously, is rapidly distributed throughout the body, for intravenous volume of distribution at steady state is about 60 liters and the total clearance of 500 ml; It is metabolized in the liver and eliminated as conjugates; The terminal elimination half-life is approximately 2.7 hours.
Renal elimination coefficient for oral / intravenous is 0.6, which can be calculated from an absorption of 60% of an orally administered dose and renal elimination of about 45%.
The unchanged drug is not metabolized by catechol-o-methyl transferase or monoamine, being eliminated mainly as conjugates with sulfuric acid.
Orciprenaline is a beta-2 adrenergic agonist with minimal action on adrenergic receptors. Exerts its actions by activation of adenyl cyclase, the enzyme that catalyzes the conversion of ATP to cAMP. Its main effect is the relaxation of bronchial smooth muscle, peripheral vascular, gastrointestinal and uterine cancer. As a adrenergic agonist influences the frequency of ciliary movements increasing mucociliary activity. Metaproterenol inhibits in vitro human histamine release in mast cells and lung tissue. After oral administration, the maximum effect of the bronchodilator activity usually occurs within 60-90 minutes and maintained between 1-5 hours.
In utero conducive hyperpolarization of the cell membrane, indirectly decreasing the uterine contractility. Administering a dose of metaproterenol uteroinhibidora produces almost immediate decrease in contractility and uterine tone, for longer than 2 hours.
Hypersensitivity to the components of the formula, hyperthyroidism, aortic subvalvular stenosis, tachyarrhythmia, hypertension. It should be assessed the risk / benefit will bring the drug in patients with recent myocardial infarction and / or severe vascular or cardiac functional alterations, as well as poorly controlled diabetes or patients taking MAO inhibitors or antidepressants tricyclics.
As with other sympathomimetic agents, ALUPENT * should be used with caution in patients with hypertension, coronary artery disease, congestive heart failure and diabetes, so patient monitoring is required especially when high doses are used, particularly when administered parenterally.
As with all drugs during the first trimester of pregnancy, ALUPENT * should only be administered under medical advice.
It must act with the same caution in the period immediately preceding the birth, because of the tocolytic effect of the active substance.
Use in Pregnancy and Lactation
The usual precautions should be observed regarding the use of drugs during pregnancy, especially during the first 3 months.
The inhibitory effect on uterine contractions should be considered during the next delivery period. The use of this medicine is not recommended during lactation.
They have reported distal tremor, nervousness, headache, dizziness, tachycardia and palpitations.
You can reach potentially have hypokalemia. Rarely they have reported decreased diastolic blood pressure, suffocation, headache, chest tightness symptoms, sleep disturbances, nausea, ventricular arrhythmias.
In patients hypersensitive to the drug have been reported or allergic skin reactions.
Beta-blockers may counteract the bronchodilator action of the drug. We will have to take special care in patients on concurrent or recent-based MAO inhibitors or tricyclic antidepressants treatment.
It should not be used simultaneously with other sympathomimetic bronchodilators, unless they are managed under the responsibility of the physician. The simultaneous use of the drug with xanthine derivatives, steroids and diuretics, can cause hypokalemia, plus hypoxia may aggravate its effects on heart rate.
Inhalation anesthetics (halothane, enflurane, isoflurane, etc.) may increase susceptibility to the cardiovascular effects of beta-adrenergic agonists.
CHANGES IN RESULTS OF LABORATORY TESTS
It can lead to false-negative or abnormally low values in prothrombin time. It can also cause false-negative or elevated values Benedict test for glucose determination.
It can result in decreased levels of calcium or potassium in the blood.
PRECAUTIONS IN RELATION TO EFFECTS OF Carcinogenesis, Mutagenesis, Impairment of Fertility
They have not been reported to date.
DOSAGE AND ADMINISTRATION
Oral, intravenous, intramuscular or subcutaneous.
The dose can be tailored to the needs and individual response.
Over 12 years and adults: For long-term treatment of bronchial asthma and bronchopulmonary diseases are accompanied by bronchospasm, the dose is ½ to 1 tablet every 6 hours.
Children 3-12 years: half a tablet every 6 hours.
Over 12 years and adults: In case of asthma attack or bronchospasm due to beta-blockers 1-2 ampoules intramuscularly or subcutaneously or intravenously average bulb slowly applied. In the case of asthma attack, it should further be administered by infusion vial diluted 1 in 100 or 50 ml isotonic to obtain a concentration of 5-10 mg / ml saline.
Children 3-12 years: ½ to 1 ampoule intramuscularly or subcutaneously.
Infants: 0.2-0.3 ml intramuscularly or subcutaneously.
Threatened abortion or premature delivery, and uterine hypertonia tachysystole: Dilute 10 vials of 0.5 mg in 250 ml of isotonic saline to a concentration of 20 ug / ml, administered by infusion at the speed of 20 drops per minute. The dose can be tailored to the needs and individual response.
Once solved the critical period, you can continue to ALUPENT * 1 tablet every 6-8 hours.
REPRESENTATIONS AND MANAGEMENT Overdosage
In case of overdose or accidental ingestion, there can be facial flushing, nausea, vomiting, hand tremors, increased pulse rate, elevated systolic blood pressure, excitement and eventually premature.
emptying and / or gastric lavage and administration of tranquilizers is recommended; in severe cases intensive care measures.
As a specific antidote should be resorted to the use of drugs beta-blockers; but in asthmatic patients we should be having the possible enhancement of the obstruction of the airways, so you must carefully set the dose of beta-blocker.
Injectable Solution: Box with 3 vials.
Tablets: Box of 30 tablets.
Injectable solution: Store in cool place.
Tablets: Store in cool, dry place.
LEGENDS OF PROTECTION
Exclusively for medical literature. Your purchase requires a medical prescription. Keep out of reach of CHILDREN.
The use of this drug during pregnancy is the responsibility of the physician.