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Medicina Mexico knows that keeping your customers happy, secure and safe is more important than making money and will always result in repeat customers.

By checking your online account, you will see your current and prior orders including your Order Number and any and all payments received. Because our staff is so busy processing orders from all over the world each day, we were forced to make some tough decisions. We are no longer taking phone calls or adding shipping information into the web servers. We do answer all emails within 24 hours and that will never stop.

All order are shipped within 48 hours of receipt of funds unless we are out of stock on a medicine. We are now informing our customers of orders that are out of stock by email. We do not provide tracking numbers unless your order is more than 30 days late beyond all custom delays. PLEASE NOTE: Medicina Mexico has no influence over any government's customs. Access to our shipping computers is no longer available to our English Sections because it resulted in that department failure to finish its daily duties.

Please NOTE: Funds received without an order number or a customer's name are placed into our SUSPENSE ACCOUNT until we are able to determine the correct owner and order number. To avoid this, please always send an email to:  sales@meds.com.mx  along with your order number and the fact that you made a payment.

The UNITED STATES and some other countries require a prescription on all medications sold from Mexico. They further require documentation in English and an invoice of all medicines sold for customs.  For these countries, Medicina Mexico is now delivering your medicines to Dr. Isaac Reyes, MD (Ced. Federal 644884) (Ced. Estatal 1537-02/05) along with the required documentation including documentation on each medication sold in English is from Wolters Kluwer.   Dr. Reyes upon receipt of your medication will issue a prescription and provide for shipping pursuant to your order.  If for any reason, Dr. Reyes fails to issue a prescription for a specific medication, then you will receive a refund or credit.

Please never send an email to more to one of our email addresses and please wait for our response. When sending in an email, please include your full name, and always include your order number and how we can help you. Each day we receive over 90,000 emails and we do not have the time to read repeative emails, nor do we remember prior emails.

Licensed pharmacies in Mexico are only allowed to sell medications, either brands or generics, from an approved pharmaceutical which has passed testing and has subsequently been authorized by the Mexican Government.

Medicina Mexico purchased a 8 million dollar AI System. When a medicine is out of stock, we will now ship the balance of your medicine. The AI will automatically order your medicine and when it arrives it will be shipped to you by our AI System.

Never take a medication without first consulting and getting permission from your MD.

If you look on the left-hand side of any of our web pages at (About US) you will see our licenses, permits and our Regulatory Body.

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Trexen Duo 100-400mg 10 Ovules

Trexen Duo 100-400mg 10 Ovules
Model:750187172064
Current Reviews:0
Price:$26.00

Trexen Duo 100-400mg 10 Ovules, Clindamycin Phosphate, Ketoconazole

THIS IS A BRAND MEDICATION

THERAPEUTIC INDICATIONS: Antibiotic and antifungal vaginal.


TREXEN DUO ® for antibiotic action is indicated for the treatment of bacterial vaginosis caused by Bacteroides spp, Gardnerella vaginalis, Mobiluncus spp, Mycoplasma hominis and other anaerobes.

For its antifungal action is indicated for the treatment of vaginal candidiasis and mixed vaginitis. The ovules of TREXEN DUO ® is a soft gelatin capsule, hydrophilic, containing clindamycin and ketoconazole cream, ovules TREXEN DUO ® dissolves with temperature and humidity of the vagina.

Pharmacokinetics in Humans: TREXEN DUO ® is clindamycin plus ketoconazole in a formulation for vaginal ovules with an antibacterial and antifungal action both specially designed for the etiological treatment of vaginal infections more common in women, bacterial vaginosis, candidiasis vaginal and mixed vaginitis.

Clindamycin is a semisynthetic derivative of lincomycin with antibiotic action against various strains of gram positive aerobic organisms such as Gardnerella vaginalis and Streptococcus viridans, microaerophilic gram-negative and anaerobic bacteria such as Bacteroides fragilis, Mobiluncus spp, Fusobacterium, within which the germs are responsible of bacterial vaginosis.

Clindamycin phosphate is inactive until it is hydrolyzed to yield free clindamycin, enzymes, phosphatases, the vaginal mucosa rapidly hydrolyze the drug after topical application.

Clindamycin has bactericidal action since it binds exclusively to the 50S subunit of bacterial ribosomes and suppresses protein synthesis. When administered clindamycin egg formulation reaches systemic absorption averaged 30%, compared with the vaginal cream reaches only 4%.

The distribution and elimination after an intravaginal application have not been fully identified, however, appears to be systemic half-life between 1.5 and 2.6 hours and is eliminated by the self-purifying mechanisms of the vagina.

Ketoconazole is an antifungal azoles group, a synthetic derivative of imidazole, with fungistatic and fungicidal action depending on the dose.

Like others in this group antifungal, ketoconazole inhibits ergosterol synthesis by blocking the demethylase lanosterol 14-alpha-dependent cytochrome P-450 is necessary to convert lanosterol to ergosterol.

Ergosterol is an essential component of the cytoplasmic membrane, by inhibiting its synthesis disrupts the membrane causing increased permeability resulting in a loss of cellular components, producing a fungistatic action.

At higher concentrations, ketoconazole may have direct physicochemical action on the cell membrane miceto, exerting a fungicide. Ketoconazole in vitro, prevents the formation of pseudohyphae in Candida, facilitating the phagocytosis of polymorphonuclear fungus.

Ketoconazole has a broad spectrum of activity including yeasts and dermatophytes.

Yeasts: Candida albicans, C. tropicalis, Malassezia ovale.

Dermatophytes: Trichophyton rubrum, T. mentagrophytes, T. tonsurans, Microsporum canis, M. audouinii, M. gypseum and Epidermophyton floccosum.

Ketoconazole applied vaginally has minimal systemic absorption. Plasma concentrations in women receiving 400 mg of ketoconazole ranging from 4 to 20.7 micrograms / ml.

Because ketoconazole applied vaginally hardly reaches the circulation, does not undergo biotransformation and is eliminated by self-cleansing mechanisms of the vagina.

CONTRAINDICATIONS: A history of hypersensitivity to clindamycin, lincomycin, ketoconazole, azole antifungal and any components of the formula.

PRECAUTIONS:

Warnings: Sexual abstinence is recommended during treatment with this product, avoid douching and using tampons.

Use in Pregnancy and Lactation: No adequate and well controlled studies in pregnant women during the first quarter.

Because animal reproduction studies are not always forecast the human response, this drug should not be used during the first trimester of pregnancy unless the physician's judgment absolutely necessary.

Lactation It is not known whether clindamycin or ketoconazole are excreted in human milk after vaginal administration due to low absorption. However, oral or parenteral, has detected the presence of clindamycin and ketoconazole in breast milk.

Hence it is decided to discontinue nursing or treatment.

ADVERSE REACTIONS: The administration of vaginal clindamycin has been associated with the following clinical manifestations, even though there have been found entirely your responsibility.

In genital tract: Cervicitis / vaginitis symptomatic candidiasis, trichomoniasis, vaginal and vulvar irritation.

With the administration of ketoconazole vaginally have reported few cases of local irritation, itching and burning, especially when starting treatment.

For low absorption of clindamycin and ketoconazole administered vaginally have not been observed systemic adverse reactions.

The soft gelatin capsule, ovule TREXEN DUO ® contains red dye no. 6 which can cause allergic reactions.

DRUG INTERACTIONS AND OTHER GENDER: Clindamycin shows cross-resistance to lincomycin and antagonistic effect in vitro with erythromycin.

CHANGES IN RESULTS OF LABORATORY TESTS: There have been demonstrated.

PRECAUTIONS IN RELATION TO EFFECTS OF CARCINOGENESIS, MUTAGENESIS, Impairment of Fertility: Systemic absorption of clindamycin as much of ketoconazole applied vaginally is minimal.

In vitro studies utililizando ketoconazole and clindamycin have shown that drugs are mutagenic.

It has been reported that ketoconazole and clindamycin administered vaginally are carcinogenic or teratogenic, they have no effect on fertility.

DOSAGE AND ADMINISTRATION:

The dose of TREXEN DUO ® is a vaginal ovule, once daily, preferably at bedtime for 7 consecutive days in pregnant patients and 5 days pregnant patient, except better opinion of the treating physician.

REPRESENTATIONS AND MANAGEMENT Overdosage: There are no reports regarding the presence of overdose with this product.
  • Drug Name: Duo Trexen
  • Brand comparison: Trexen Duo
  • Active ingredient: clindamycin phosphate /
  • ketoconazole
  • Presentation: Ovules
  • Concentration: 100-400mg
  • Response time: No
  • Laboratory Asofarma, S. A. de CV
  • Egg Box with 7 ovules
  • Manufactured in: Mexico






   
   
   
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