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Tetracycline (Biotricina) 500mg 10 Tabs, Tetraciclina
THERAPEUTIC INDICATIONS: Biotricina (tetracycline) is highly effective in the treatment of infections caused by: recurrentis Borrelia (relapsing fever); Calymmatobacterium granulomatis (granuloma inguinale), Chlamydia sp (psittacosis, lymphogranuloma venereum, trachoma, conjunctivitis, pelvic inflammatory syndrome chronic), Francisella tularensis (tularemia), Haemophilus ducreyi (chancroid), Leptospira (meningitis, jaundice), Mycoplasma pneumoniae (NGU), Pseudomonas mallei and pseudomallei Rickettsia (epidemic typhus, Q fever, spotted fever Rocky Mountain) Vibrio sp (cholera), Bordetella pertussis (whooping cough), Bartonella bacilliformis, Campylobacter fetus, jejuni, Pasteurella multocida, Spirillum minor (rat-bite fever), Streptobacillus moniliformis (bite fever). It is also highly effective alone or in combination with streptomycin in the treatment of infections due to Brucella species (brucellosis) and Yersinia pestis (bubonic plague) and Propionibacterium acnes (acne vulgaris). Other susceptible organisms include Actinomyces isrealii, Bacillus anthracis (pneumonia), Clostridium sp (gas gangrene, tetanus), Entamoeba histolytica (bacterial dysentery), Neisseria gonorrhoeae, Treponema pallidum and pertenue (syphilis and yaws).
CONTRAINDICATIONS: Known hypersensitivity to tetracyclines. Severe liver or renal failure, hemorrhagic states, albuminuria, hematuria, gastritis, and in patients younger than 8 years, pregnant and lactating women.
RESTRICTIONS OF USE DURING PREGNANCY AND LACTATION:
Use in Pregnancy: Results from animal studies indicate that tetracyclines cross the placenta, are amounts of tetracycline in fetal tissues and can have toxic effects on the developing fetus (retardation in skeletal development).
It has also been evidence of embryotoxicity observed in animals treated during the early stages of pregnancy. So Biotricina should not be used during pregnancy, unless considered essential in which case the maximum daily dose should not be more than a gram.
The use of tetracyclines during tooth development (5th. To the 9th. Month of pregnancy) can cause permanent tooth discoloration (yellow-gray-brown). This adverse reaction is more common with long-term use, but has also been observed after repeated treatments of short duration. Also reported enamel hypoplasia.
Use in lactation: Following intake, tetracycline has been found in the milk of lactating women. As the permanent tooth discoloration may occur in the developing child and has been reported enamel hypoplasia consequently Biotricina should not be administered to nursing women.
DOSAGE AND ADMINISTRATION:
adults:
Moderate infections: The usual daily dose is 1 g per day (500 mg every 12 hours or 250 mg c/ 6 hours). The dose may be increased to 2 g in severe infections.
Children older than 8 years: 25 to 50 mg / kg / day in four equal doses. The maximum doseshould not exceed the recommended dose for adults.
TETRA-ZIL ® should be administered one hour before or 2 hours after meals.
Therapy should be continued until three days after the characteristic symptoms of the infection have disappeared.
For children over 8 years of age: The usual dose is 25 to 50 mg / kg / day in 4 equal doses.
In patients with renal failure the total dose should be decreased by reducing the recommended dose or extending the interval between doses.
Treatment should continue for at least 24 to 48 hours after symptoms and fever have subsided.
